Jitske Janssen won the award for best fundamental research abstract at the Dutch Nephrology Days for her abstract on the use of human induced pluripotent stem cell-derived kidney organoid to model nephrotic syndrome.
The Dutch Kidney Foundation supports talented postdocs and physician researchers. Kolff grant recipients are foreseen to make important contributions to the field of renal research and to stimulate the application of research results in practice.
Dr. Jitske Jansen, member of the nephropathology research group, has received a Veni grant of 250,000 Euro from the Netherlands Organization for Scientific Research (NWO). Project title: The REPAIR study: Regeneration of kidnEy ePitheliAl cells crossIng boRders
Nephrologist and kidney researchers in collaboration with kidney patients and NierNieuws organize a playful teaching program at Radboud University Medical Center to raise awareness for kidney disease.
Interview with Dr. Jitske Jansen for NierNieuws (Kidney News). March 2019 An interview with researcher Jitske Jansen from the Radboudumc Amalia Children’s Hospital in Nijmegen about her research on organoids. “Mini-niertjes in een kweekschaaltje” (article in Dutch).
Our recent publication in Pediatric Nephrology. February 2019 Nephrotic syndrome in a dish: recent developments in modeling in vitro. In this review, we highlight the molecular basis of nephrotic syndrome and discuss requirements to accurately study nephrotic syndrome in vitro, including an overview of specific podocyte markers, cutting-edge stem cell organoids, and the implementation of microfluidic platforms. The development of (patho) physiologically relevant glomerular models will accelerate the identification of molecular targets involved in nephrotic syndrome and may be the harbinger of a new era of therapeutic avenues.
A huge surface A microscopic image scan of a cross-section of a mouse kidney. Different microscopic images are digitally stitched together to create this image. The bright fluorescent green structures are the brush borders within the kidney. Both kidneys together filter 200 liters of fluid every 24 hours. The filtrate is further processed and concentrated to the 1,5 liter of urine we normally pee throughout the day. The filtrate is processed in specialized tubes (nephrons). A human kidney has about one million nephrons, and the total length of the nephrons in the kidney is about 40 miles! The inside of …
An illuminating cross-section of a kidney A microscopic image scan of a whole mouse kidney. Different microscopic images are digitally stitched together to create this image. The bright fluorescent red structures are the proximal tubuli of the kidney. The nuclei of kidney cells are stained blue. The nuclei of a subpopulation of cells is labeled by a green fluorescent protein.
“Bright” podocytes A microscopic image scan of a whole mouse kidney. Different microscopic images are digitally stitched together to create this image. The bright fluorescent cells are podocytes. This cell type is important for the filtration of the blood. The podocyte cell body is stained in green and the nucleus in pink. Using these fluorescent markers, we can visualize the podocytes and thus the glomeruli (the kidney filters).
A beautiful pattern Fluorescence image of the kidney papilla, which contain tubules that are normally busy processing your urine. The so-called collecting ducts are depicted in green. In red one can see the thin loops of Henle and blood vessels (vasa rectae).