Nephrotic syndrome in a dish

Our recent publication in Pediatric Nephrology. February 2019

Nephrotic syndrome in a dish: recent developments in modeling in vitro.

In this review, we highlight the molecular basis of nephrotic syndrome and discuss requirements to accurately study nephrotic syndrome in vitro, including an overview of specific podocyte markers, cutting-edge stem cell organoids, and the implementation of microfluidic platforms. The development of (patho) physiologically relevant glomerular models will accelerate the identification of molecular targets involved in nephrotic syndrome and may be the harbinger of a new era of therapeutic avenues.