“Bright” podocytes

    “Bright” podocytes A microscopic image scan of a whole mouse kidney. Different microscopic images are digitally stitched together to create this image. The bright fluorescent cells are podocytes. This cell type is important for the filtration of the blood. The podocyte cell body is stained in green and the nucleus in pink. Using these fluorescent markers, we can visualize the podocytes and thus the glomeruli (the kidney filters).

Continue Reading

A surprising finding

A surprising finding! These kidney epithelial cells in culture were ignored for several weeks. The cells normally grow as a monolayer on the bottom of the culture flask. Without the necessary care and fresh nutrition, the cells changed their behavior and started to form spheres that were filled with extracellular matrix. This was never shown for this cell type. A finding that was interesting but difficult to reproduce. Nevertheless, a surprising finding.

Continue Reading

Our recent publication in Kidney Int.

Kidney Int. March 2018, p626–642 CD44 is required for the pathogenesis of experimental crescentic glomerulonephritis and collapsing focal segmental glomerulosclerosis. J. Eymael et al. A key feature of glomerular diseases such as crescentic glomerulonephritis and focal segmental glomerulosclerosis is the activation, migration and proliferation of parietal epithelial cells. CD44-positive activated parietal epithelial cells have been identified in proliferative cellular lesions in glomerular disease. However, it remains unknown whether CD44-positive parietal epithelial cells contribute to the pathogenesis of scarring glomerular diseases. Here, we evaluated this in experimental crescentic glomerulonephritis and the transgenic anti-Thy1.1 model for collapsing focal segmental glomerulosclerosis in CD44-deficient (cd44-/-) …

Continue Reading
jitske mic

Older news items

Bart Smeets was selected for the Radboud Hypatia Track. The Radboud Hypatia Track is aimed at excellent researchers who are ready to develop themselves as leaders within their academic fields. Jennifer Eymael won the ‘Best presentation award’ at the “Junge Niere” meeting of the Deutsche Gesellschaft für Nefrologie (DGfN). Jennifer Eymael was awarded with a travel grant for the German annual nephrology congress 2017, Mannheim, Germany. Bart Smeets received the Radboudumc Hypatia Tenure Track grant. Bart Smeets was award winner of the Dr. Werner Jackstädt Research Award 2014. This award is for the promotion and award of outstanding scientists in …

Continue Reading